Solubility Enhancement of Rifabutin by Co-solvency Approach

Rifabutin is wide spectrum antimicrobial agent, effective in the treatment of infection caused by M. tuberculosis, avium and Leprae also used multidrug resistant TB. very poorly water soluble drug (0.19mg/ml) with high permeability. For enhancement solubility a hydrophobic has significant role development liquid dosages form. The main purpose this study was to improve co solvency method. Different blends were prepared usinf different solvents surfactants proportions have been enhance like water, phosphate buffer, ethanol, propylene glycol PEG 400, Tween 80 Brij 35. In thisit found that blend 90% 10% (ethanol glycol) give highest among surfactant systems, had shown enhanced Rifabutin. Solubility rifabutin determined preparing saturated solutions pure mixture or without surfactants. It observed ethanol better improvement when compared other as it noteworthy 1.6803 mg/ml.The above observations lead propose addition small amount polar solvent enhances drug.Thus, generated an important array data compare effect these cosolvents on aqueous rifabutin.